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The compound formulation brings these two evidence-based ingredients together based on a theoretical rationale about complementary mechanisms, not on direct combination studies

Observational studies have added further evidence

Normally, the astroglial glutamate transporters GLT-1 and GLAST take up glutamate to mediate a high signal-to-noise ratio in the synaptic signalling, and also to prevent excitotoxic effects by glutamate

Patients with a history of medullary thyroid carcinoma, personal or family history of multiple endocrine neoplasia type 2 (MEN2), or severe diabetic retinopathy should not use semaglutide